| dc.contributor.advisor | Mossammat Rima Akter | en_US |
| dc.contributor.author | Jeba, Noshin Rumali | |
| dc.date.accessioned | 2026-09-28T07:11:10Z | |
| dc.date.available | 2026-09-28T07:11:10Z | |
| dc.date.issued | 2026-09 | |
| dc.identifier.other | ID 2130365 | |
| dc.identifier.uri | https://ar.iub.edu.bd/handle/11348/1623 | |
| dc.description | This industrial internship report is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy from the Department of Pharmacy, 2026. | |
| dc.description.abstract | This study established a collagen-induced arthritis (CIA) model in 18 male Sprague-Dawley rats using chicken type II collagen and Complete Freund’s Adjuvant (CFA) to investigate rheumatoid arthritis and evaluate a potential treatment. The rats were divided into control and treatment groups and monitored for swelling, redness, movement, paw edema, arthritis scores, radiographic changes, and inflammatory markers. Arthritis-induced rats showed noticeable joint inflammation, reduced movement, paw edema, and bone erosion compared with controls. Although IL-6 and CRP levels remained below the detection thresholds in the tested samples, the overall findings indicate that the induction protocol successfully produced an inflammatory arthritis phenotype suitable for evaluating anti-arthritic treatments. | en_US |
| dc.format.extent | 35 pages | |
| dc.language.iso | en | en_US |
| dc.publisher | Independent University, Bangladesh (IUB) | en_US |
| dc.rights | Theses submitted to Independent University, Bangladesh are protected by copyright. They may be accessed for academic and research purposes; however, reproduction, distribution, or use of the material in any form requires prior written permission from the University. | |
| dc.subject | Rheumatoid arthritis | en_US |
| dc.subject | Collagen-induced arthritis | en_US |
| dc.subject | Type II collagen | en_US |
| dc.subject | Complete Freund's Adjuvant | en_US |
| dc.subject | Sprague-Dawley rats | en_US |
| dc.subject | Paw edema | en_US |
| dc.subject | Arthritis score | en_US |
| dc.subject | Bone erosion | en_US |
| dc.title | Development of collagen-induced arthritis in male Sprague-Dawley rats using type ii chicken collagen and complete Freund’s adjuvant | en_US |
| dc.type | Thesis | en_US |
| dc.contributor.department | Department of Pharmacy | |
