| dc.contributor.author | Samad, Mehdi Bin | |
| dc.contributor.author | Mohsin, Md Nurul Absar Bin | |
| dc.contributor.author | Razu, Bodiul Alam | |
| dc.contributor.author | Hossain, Mohammad Tashnim | |
| dc.contributor.author | Mahzabeen, Sinayat | |
| dc.contributor.author | Unnoor, Naziat | |
| dc.contributor.author | Muna, Ishrat Aklima | |
| dc.contributor.author | Akhter, Farjana | |
| dc.contributor.author | Kabir, Ashraf Ul | |
| dc.contributor.author | Hannan, J M A | |
| dc.date.accessioned | 2020-12-02T05:03:04Z | |
| dc.date.available | 2020-12-02T05:03:04Z | |
| dc.date.issued | 2020-11-02 | |
| dc.identifier.uri | https://ar.iub.edu.bd/handle/11348/530 | |
| dc.description.abstract | [6]-Gingerol, a major component of Zingiber officinale, was previously reported to ameliorate hyperglycemia in type 2 diabetic mice. Endocrine signaling is involved in insulin secretion and is perturbed in db/db Type-2 diabetic mice. [6]-Gingerol was reported to restore the disrupted endocrine signaling in rodents. In this current study on Leprdb/db diabetic mice, we investigated the involvement of endocrine pathway in the insulin secretagogue activity of [6]-Gingerol and the mechanism(s) through which [6]-Gingerol ameliorates hyperglycemia. | en_US |
| dc.description.sponsorship | ; ; ; Leprdb/db mice; ; Rab27a; Rab8; Type 2 diabetes; [6]-Gingerol | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | National Library of Medicine | en_US |
| dc.subject | GLP-1 | en_US |
| dc.subject | GLUT4 | en_US |
| dc.subject | Glycogen synthase 1 | en_US |
| dc.subject | Leprdb/db mice | en_US |
| dc.subject | Rab10 | en_US |
| dc.subject | [6]-Gingerol | en_US |
| dc.title | [6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic β-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Lepr db/db type 2 diabetic mice | en_US |
| dc.type | Article | en_US |
